Stem Cell Environment and Skeletal Muscle Homeostasis


  • Hilmi M, Jouinot A, Burns R, Pigneur F, Mounier R, Gondin J, Neuzillet C & Goldwasser F.
    Body composition and sarcopenia: The next-generation of personalized oncology and pharmacology? Pharmacol Ther. 2018 (In press).
  • Juban G, Saclier M, Yacoub-Youssef H, Kernou A, Arnold L, Boisson C, Ben Larbi S, Magnan M, Cuvellier S, Théret M, Petrof BJ, Desguerre I, Gondin J, Mounier R & Chazaud B.
    AMPK activation regulates LTBP4-dependent TGF-β1 secretion by pro-inflammatory macrophages and controls fibrosis in Duchenne Muscular Dystrophy. Cell Rep. 2018 25:2163-2176.
  • Verma M, Asakura Y, Murakonda BSR, Pengo T, Latroche C, Chazaud B, McLoon LK & Asakura A.
    Muscle Satellite Cell Cross-talk with a vascular niche maintains quiescence via VEGF and Notch signaling. Cell Stem Cell. 2018 23:530-543.e9.
  • McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa J, Reutelingsperger C, Perretti M & Mounier R.
    Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. bioRxiv 375709; doi:
  • Latroche C, Weiss-Gayet M & Chazaud B.
    Investigating the vascular niche: three-dimension co-culture of human skeletal muscle stem cells and endothelial cells Methods Mol Biol. 2018 (In press).
  • Messineo AM, Gineste C, Sztal TE, McNamara EL, Vilmen C, Ogier AC, Hahne D, Bendahan D, Laing NG, Bryson-Richardson RJ, Gondin J & Nowak KJ.
    L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy. Sci Rep. 2018 8:11490.
  • Theret M, Gsaier L, Ben Larbi S, Weiss-Gayet M & Mounier R.
    Analysis of muscle stem cell fate through modulation of AMPK activity. Methods Mol Biol. 2018 1732:539-49.
  • Le Moal E, Juban G, Bernard AS, Varga T, Policar C, Chazaud B & Mounier R.
    Macrophage-derived superoxide production and antioxidant response following skeletal muscle injury. Free Radic Biol Med. 2018 120:33-40.
  • Fouré A, Ogier AC, Le Troter A, Vilmen C, Feiweier T, Guye M, Gondin J, Besson P & Bendahan D.
    Diffusion properties and 3d architecture of human lower leg muscles assessed with ultra-high-field-strength diffusion-tensor MR imaging and tractography: reproducibility and sensitivity to sex difference and intramuscular variability. Radiology. 2018 287:592-607.
  • Theret M, Gsaier L & Mounier R.
    AMPKα1-LDHA, a new metabolic pathway, regulating stem cell fate. Cell Cycle. 2018 17:403-4.
  • Latroche C, Weiss-Gayet M, Gitiaux C & Chazaud B.
    Cell sorting of various cell types from mouse and human skeletal muscle. Methods. 2018 134-135:50-55.
  • Maffiuletti NA, Gondin J, Place N, Stevens-Lapsley J, Vivodtzev I & Minetto MA.
    The clinical use of neuromuscular electrical stimulation for neuromuscular rehabilitation: what are we overlooking? Arch Phys Med Rehabil. 2018 99:806-12.
  • Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B & Lantier L.
    AMPK in skeletal muscle function and metabolism. FASEB J. 2018 32:1741-77.
  • Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME & Vénéreau E.
    High mobility group box 1 orchestrates tissue regeneration via CXCR4. J Exp Med. 2018 215:303-18.
  • Neyroud D, Grosprêtre S, Gondin J, Kayser B & Place N.
    Test-retest reliability of wide-pulse high-frequency neuromuscular electrical stimulation evoked force. Muscle Nerve. 2018 57:E70-7.
  • Gitiaux C, Latroche C, Weiss-Gayet M, Rodero MP, Duffy D, Bader-Meunier B, Glorion C, Nusbaum P, Bodemer C, Mouchiroud G, Chelly J, Germain S, Desguerre I & Chazaud B.
    Myogenic progenitor cells exhibit type I interferon-driven proangiogenic properties and molecular signature during juvenile dermatomyositis. Arthritis Rheumatol. 2018 70:134-45.


  • Latroche C, Weiss-Gayet M, Muller L, Gitiaux C, Leblanc P, Liot S, Ben-Larbi S, Abou-Khalil R, Verger N, Bardot P, Magnan M, Chrétien F, Mounier R, Germain S & Chazaud B.
    Coupling between myogenesis and angiogenesis during skeletal muscle regeneration is stimulated by restorative macrophages. Stem Cell Reports. 2017 9:2018-33.
  • Wegrzyk J, Ranjeva JP, Fouré A, Kavounoudias A, Vilmen C, Mattei JP, Guye M, Maffiuletti NA, Place N, Bendahan D & Gondin J.
    Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols. Sci Rep. 2017 7:2742.
  • Jubeau M & Gondin J.
    Methodological considerations for investigating the influence of neuromuscular electrical stimulation on pH heterogeneity. Magn Reson Med. 2017 77:465.
  • Morel J, Palao JC, Castells J, Desgeorges M, Busso T, Molliex S, Jahnke V, Del Carmine P, Gondin J, Arnould D, Durieux AC & Freyssenet D.
    Regulation of Akt-mTOR, ubiquitin- proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice. Sci Rep. 2017 7:10866.
  • Juban G & Chazaud B.
    Metabolic regulation of macrophages during tissue repair: insights from skeletal muscle regeneration. FEBS Lett. 2017 591:3007-21.
  • Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B & Mounier R.
    AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J. 2017 36: 1946-62.
  • Mounier R & Chazaud B.
    PPARγ transcription factor controls in anti-inflammatory macrophages the expression of GDF3 that stimulates myogenic cell fusion during skeletal muscle regeneration. Med Sci (Paris). 2017 33:466-9.
  • Mackey AL, Magnan M, Chazaud B & Kjaer M.
    Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration. J Physiol. 2017 595:5115-27.
  • Le Moal E, Pialoux V, Juban G, Groussard C, Zouhal H, Chazaud B & Mounier R.
    Redox Control of Skeletal Muscle Regeneration. Antioxid Redox Signal. 2017 27:276-310.
  • Saclier M, Theret M, Mounier R & Chazaud B.
    Effects of Macrophage Conditioned-Medium on Murine and Human Muscle Cells: Analysis of Proliferation, Differentiation, and Fusion. Methods Mol Biol. 2017 1556:317-27.


  • Varga T, Mounier R, Patsalos A, Gogolák P, Peloquin M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E, Poliska S, Cuvellier S, Ben Larbi S, Sansbury BE, Spite M, Brown CW, Chazaud B & Nagy L.
    Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration. Immunity. 2016 45:1038-51.
  • Veldman MP, Gondin J, Place N & Maffiuletti NA.
    Effects of Neuromuscular Electrical Stimulation Training on Endurance Performance. Front Physiol. 2016 7:544.
  • Varga T, Mounier R, Horvath A, Cuvellier S, Dumont F, Poliska S, Ardjoune H, Juban G, Nagy L & Chazaud B.
    Highly dynamic transcriptional signature of distinct macrophage subsets during sterile inflammation, resolution, and tissue repair. J Immunol. 2016 196:4771-82.
  • Weiss-Gayet M, Starck J, Chaabouni A, Chazaud B & Morlé F.
    Notch stimulates both self-renewal and lineage plasticity in a subset of murine CD9high committed megakaryocytic progenitors. PLoS One. 2016 11:e0153860.
  • Chazaud B.
    Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management. Immunol Cell Biol. 2016 94:140-5.
  • Gitiaux C, De Antonio M, Aouizerate J, Gherardi RK, Guilbert T, Barnerias C, Bodemer C, Brochard-Payet K, Quartier P, Musset L, Chazaud B, Desguerre I & Bader-Meunier B.
    Vasculopathy-related clinical and pathological features are associated with severe juvenile dermatomyositis. Rheumatology. 2016 55:470-9.


  • Arnold L, Perrin H, de Chanville CB, Saclier M, Hermand P, Poupel L, Guyon E, Licata F, Carpentier W, Vilar J, Mounier R, Chazaud B, Benhabiles N, Boissonnas A, Combadiere B & Combadiere C.
    CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nat Commun. 2015 6:8972.
  • Latroche C, Gitiaux C, Chrétien F, Desguerre I, Mounier R & Chazaud B.
    Skeletal muscle microvasculature: a highly dynamic lifeline. Physiology. 2015 30:417-27.
  • Carras S, Valayer A, Moratal C, Weiss-Gayet M, Pages G, Morlé F, Mouchiroud G & Gobert S.
    Instructive role of M-CSF on commitment of bipotent myeloid cells involves ERK-dependent positive and negative signaling. J Leukoc Biol. 2015 185:2482-94.
  • Chan KL, Pillon NJ, Sivaloganathan DM, Costford SR, Liu Z, Theret M, Chazaud B & Klip A.
    Palmitoleate reverses high fat-induced pro-inflammatory macrophage polarization via AMPK. J Biol Chem. 2015 290:16979-88.
  • Gondin J, Theret M, Duhamel G, Pegan K, Mathieu JR, Peyssonnaux C, Cuvellier S, Latroche C, Chazaud B, Bendahan D & Mounier R.
    Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration. J Immunol. 2015 194:3389-99.
  • Mounier R, Theret M, Lantier L, Foretz M & Viollet B.
    Expanding roles for AMPK in skeletal muscle plasticity. Trends Endocrinol Metab. 2015 26:275-86.
  • Latroche C, Matot B, Martins-Bach A, Briand D, Chazaud B, Wary C, Carlier PG, Chrétien F & Jouvion G.
    Structural and functional alterations of skeletal muscle microvasculature in dystrophin-deficient mdx mice. Am J Pathol. 2015 185:2482-94.
  • Matak P, Heinis M, Mathieu JR, Corriden R, Cuvellier S, Delga S, Mounier R, Rouquette A, Raymond J, Lamarque D, Emile JF, Nizet V, Touati E & Peyssonnaux C.
    Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. J Immunol. 2015 194:3259-66.


  • Chazaud B & Mouchiroud G.
    Inflamm-aging: STAT3 signaling pushes muscle stem cells off balance. Cell Stem Cell. 2014 15:401-2.
  • Chazaud B.
    Macrophages: supportive cells for tissue repair and regeneration. Immunobiology. 2014 219:172-8.
  • Figeac F, Lesault PF, Le CO, Damy T, Souktani R, Trebeau C, Schmitt A, Ribot J, Mounier R, Guguin A, Manier C, Surenaud M, Hittinger L, Dubois-Rande JL & Rodriguez AM.
    Nanotubular crosstalk with distressed cardiomyocytes stimulates the paracrine repair function of mesenchymal stem cells. Stem Cells. 2014 32:216-30.
  • Lantier L, Fentz J, Mounier R, Leclerc J, Treebak JT, Pehmoller C, Sanz N, Sakakibara I, Saint-Amand E, Rimbaud S, Maire P, Marette A, Ventura-Clapier R, Ferry A, Wojtaszewski JF, Foretz M & Viollet B.
    AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity. FASEB J. 2014 28:3211-24.


  • Abou-Khalil R, Le Grand F & Chazaud B.
    Human and murine skeletal muscle reserve cells. Methods Mol Biol. 2013 1035:165-77.
  • Mounier R, Theret M, Arnold L, Cuvellier S, Bultot L, Goransson O, Sanz N, Ferry A, Sakamoto K, Foretz M, Viollet B & Chazaud B.
    AMPKalpha1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab. 2013 18:251-64.
  • Saclier M, Yacoub-Youssef H, Mackey AL, Arnold L, Ardjoune H, Magnan M, Sailhan F, Chelly J, Pavlath GK, Mounier R, Kjaer M & Chazaud B.
    Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration. Stem Cells. 2013 31:384-96.
  • Saclier M, Cuvellier S, Magnan M, Mounier R & Chazaud B.
    Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration. FEBS J. 2013 280:4118-30.
  • Varga T, Mounier R, Gogolak P, Poliska S, Chazaud B & Nagy L.
    Tissue LyC6- macrophages are generated in the absence of circulating LyC6- monocytes and Nur77 in a model of muscle regeneration. J Immunol. 2013 191:5695-701.


  • Bencze M, Negroni E, Vallese D, Yacoub-Youssef H, Chaouch S, Wolff A, Aamiri A, Di Santo JP, Chazaud B, Butler-Browne G, Savino W, Mouly V & Riederer I.
    Proinflammatory macrophages enhance the regenerative capacity of human myoblasts by modifying their kinetics of proliferation and differentiation. Mol Ther. 2012 20:2168-79
  • Desguerre I, Arnold L, Vignaud A, Cuvellier S, Yacoub-Youssef H, Gherardi RK, Chelly J, Chretien F, Mounier R, Ferry A & Chazaud B.
    A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophy. Muscle Nerve. 2012 45:803-14.
  • Joanne P, Hourde C, Ochala J, Cauderan Y, Medja F, Vignaud A, Mouisel E, Hadj-Said W, Arandel L, Garcia L, Goyenvalle A, Mounier R, Zibroba D, Sakamoto K, Butler-Browne G, Agbulut O & Ferry A.
    Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle. PLoS One. 2012 7:e35346.
  • Lesault PF, Theret M, Magnan M, Cuvellier S, Niu Y, Gherardi RK, Tremblay JP, Hittinger L & Chazaud B.
    Macrophages improve survival, proliferation and migration of engrafted myogenic precursor cells into MDX skeletal muscle. PLoS One. 2012 7:e46698.
  • Mounier R & Brugniaux JV.
    Counterpoint: Hypobaric hypoxia does not induce different responses from normobaric hypoxia. J Appl Physiol. 2012 112:1784-6.
  • Mounier R & Brugniaux JV.
    Last word on Counterpoint: Hypobaric hypoxia does not induce different physiological responses from normobaric hypoxia. J Appl Physiol. 2012 112:796.
  • Pialoux V & Mounier R.
    Hypoxia-induced oxidative stress in health disorders. Oxid Med Cell Longev. 2012 2012:940121.


  • Mounier R, Chretien F & Chazaud B.
    Blood vessels and the satellite cell niche. Curr Top Dev Biol. 2011 96:121-38.
  • Mounier R, Amonchot A, Caillot N, Gladine C, Citron B, Bedu M, Chirico E, Coudert J & Pialoux V.
    Pulmonary arterial systolic pressure and susceptibility to high altitude pulmonary edema. Respir Physiol Neurobiol. 2011 179:294-9.
  • Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Foretz M & Viollet B.
    Antagonistic control of muscle cell size by AMPK and mTORC1. Cell Cycle. 2011 10:2640-6.
  • Pournot H, Bieuzen F, Louis J, Mounier R, Fillard JR, Barbiche E & Hausswirth C.
    Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise. PLoS One. 2011 6:e22748.


  • Abou-Khalil R, Mounier R & Chazaud B.
    Regulation of myogenic stem cell behavior by vessel cells: the "menage a trois" of satellite cells, periendothelial cells and endothelial cells. Cell Cycle. 2010 9:892-6.
  • Chazaud B.
    Dual effect of HGF on satellite/myogenic cell quiescence. Focus on "High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo". Am J Physiol Cell Physiol. 2010 298:C448-9.
  • de Luna N, Gallardo E, Sonnet C, Chazaud B, Dominguez-Perles R, Suarez-Calvet X, Gherardi RK & Illa I.
    Role of thrombospondin 1 in macrophage inflammation in dysferlin myopathy. J Neuropathol Exp Neurol. 2010 69:643-53.
  • Krogh-Madsen R, Thyfault JP, Broholm C, Mortensen OH, Olsen RH, Mounier R, Plomgaard P, van HG, Booth FW & Pedersen BK.
    A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity. J Appl Physiol. 2010 108:1034-40.
  • Lantier L, Mounier R, Leclerc J, Pende M, Foretz M & Viollet B.
    Coordinated maintenance of muscle cell size control by AMP-activated protein kinase. FASEB J. 2010 24:3555-61.
  • Mounier R, Pedersen BK & Plomgaard P.
    Muscle-specific expression of hypoxia-inducible factor in human skeletal muscle. Exp Physiol. 2010 95:899-907.
  • Pialoux V, Brugniaux JV, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Clottes E, Coudert J, Fellmann N & Mounier R.
    Antioxidant status of elite athletes remains impaired 2 weeks after a simulated altitude training camp. Eur J Nutr. 2010 49:285-92.
  • Yfanti C, Akerstrom T, Nielsen S, Nielsen AR, Mounier R, Mortensen OH, Lykkesfeldt J, Rose AJ, Fischer CP & Pedersen BK.
    Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc. 2010 42:1388-95.


  • Abou-Khalil R, Le GF, Pallafacchina G, Valable S, Authier FJ, Rudnicki MA, Gherardi RK, Germain S, Chretien F, Sotiropoulos A, Lafuste P, Montarras D & Chazaud B.
    Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell. 2009 5:298-309.
  • Chazaud B, Brigitte M, Yacoub-Youssef H, Arnold L, Gherardi R, Sonnet C, Lafuste P & Chretien F.
    Dual and beneficial roles of macrophages during skeletal muscle regeneration. Exerc Sport Sci Rev. 2009 37:18-22.
  • Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Pende M, Daegelen D, Sakamoto K, Foretz M & Viollet B.
    Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy. FASEB J. 2009 23:2264-73.
  • Mounier R, Pialoux V, Schmitt L, Richalet JP, Robach P, Coudert J, Clottes E & Fellmann N.
    Effects of acute hypoxia tests on blood markers in high-level endurance athletes. Eur J Appl Physiol. 2009 106:713-20.
  • Mounier R, Pialoux V, Roels B, Thomas C, Millet G, Mercier J, Coudert J, Fellmann N & Clottes E.
    Effect of intermittent hypoxic training on HIF gene expression in human skeletal muscle and leukocytes. Eur J Appl Physiol. 2009 105:515-24.
  • Pialoux V, Mounier R, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Coudert J & Fellmann N.
    Effects of acute hypoxic exposure on prooxidant/antioxidant balance in elite endurance athletes. Int J Sports Med. 2009 30:87-93.
  • Pialoux V, Mounier R, Brown AD, Steinback CD, Rawling JM & Poulin MJ
    Relationship between oxidative stress and HIF-1 alpha mRNA during sustained hypoxia in humans. Free Radic Biol Med. 2009 46:321-6.
  • Pialoux V, Mounier R, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Brugniaux J, Coudert J & Fellmann N.
    Effects of the 'live high-train low' method on prooxidant/antioxidant balance on elite athletes. Eur J Clin Nutr. 2009 63:756-62.
  • Pialoux V, Mounier R & Brugniaux JV.
    Hemoglobin and hematocrit are not such good candidates to detect autologous blood doping. Int J Hematol. 2009 89:714-5.
  • Pialoux V, Mounier R, Brugniaux JV, Rock E, Mazur A, Richalet JP, Robach P, Coudert J & Fellmann N.
    Thirteen days of "live high-train low" does not affect prooxidant/antioxidant balance in elite swimmers. Eur J Appl Physiol. 2009 106:517-24.
  • Pialoux V, Brugniaux JV, Fellmann N, Richalet JP, Robach P, Schmitt L, Coudert J & Mounier R.
    Oxidative stress and HIF-1 alpha modulate hypoxic ventilatory responses after hypoxic training on athletes. Respir Physiol Neurobiol. 2009 167:217-20.
  • Viollet B, Guigas B, Leclerc J, Hebrard S, Lantier L, Mounier R, Andreelli F & Foretz M.
    AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol. 2009 196 :81-98.
  • Viollet B, Athea Y, Mounier R, Guigas B, Zarrinpashneh E, Horman S, Lantier L, Hebrard S, Devin-Leclerc J, Beauloye C, Foretz M, Andreelli F, Ventura-Clapier R & Bertrand L.
    AMPK: Lessons from transgenic and knockout animals. Front Biosci. 2009 14:19-44.
  • Viollet B, Lantier L, Devin-Leclerc J, Hebrard S, Amouyal C, Mounier R, Foretz M & Andreelli F.
    Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci. 2009 14:3380-400.